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Prometrium Progesterone (100mg) 30 Capsules

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Code: 10037487
This product is a Prescription Only Medicine (S4) and is sold by Healthylife Pharmacy, an indepedently owned and operated pharmacy business.
    Code: 10037487
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Prometrium Progesterone (100mg) 30 Capsules


PROMETRIUM 100 and 200 mg

Progesterone (micronised) 100 and 200 mg, soft capsule 
(For oral use)

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Prometrium.

The leaflet does not contain all the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you taking Prometrium against the benefits this medicine is expected to have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again.

What Prometrium is used for

Prometrium is provided as a soft capsule that contains the natural female hormone, progesterone for oral use.

Prometrium is for women for the treatment of menstrual abnormalities or secondary amenorrhoea (no menstrual periods) and as hormone replacement therapy (HRT) in combination with oestrogen in postmenopausal women with an intact uterus (womb).

Your doctor may have prescribed Prometrium for another purpose. Ask your doctor if you have any questions why this medicine has been prescribed for you.

Prometrium is available only with a doctor’s prescription.

This medicine is not addictive.

This medicine is not a contraceptive.

Before you take Prometrium

When you must not take it

Do not take Prometrium if you have an allergy to:

  • any medicine containing progesterone
  • any of the ingredients listed at the end of this leaflet.

Symptoms of an allergic reaction may include:

  • skin rash, itching or hives
  • swelling of the face, lips, tongue or other parts of the body
  • shortness of breath, wheezing or difficulty breathing.

Do not take Prometrium if you have or have had any of the following conditions:

  • unusual vaginal bleeding that has not been evaluated by your doctor
  • known missed abortions or ectopic pregnancy
  • severe liver problems
  • known or suspected cancer of the breast or genital tract
  • blood clots (thrombophlebitis or thromboembolic disorder), such as inflammation of a vein, deep vein blood clotting (thrombosis) or a blood clot that travelled to the lungs (pulmonary embolism)
  • bleeding on the brain
  • porphyria disorder (a blood disease).

Do not take Prometrium if you are pregnant or intend to become pregnant. If you get pregnant while taking Prometrium, stop taking it straight away and tell your doctor.

Do not take Prometrium if you are breast-feeding.

Do not give Prometrium to a child of any age.

Do not take Prometrium after the expiry date printed on the pack.

Do not take Prometrium if the packaging is torn, shows signs of tampering, or if the product does not look quite right. If it has expired or if the packaging is damaged, return it to your pharmacist or doctor for disposal.

If you are not sure whether you should start taking Prometrium talk to your doctor.

Before you start to take it

Before starting or recommencing progesterone therapy, a physical examination should have been performed including special attention to the breasts, abdomen and pelvic organs.

Tell your doctor or pharmacist if you have allergies to:

  • any other medicines
  • any other substances, such as foods, preservatives or dyes.

You must tell your doctor or pharmacist if you have or have had any of the following problems:

  • epilepsy
  • migraine
  • high blood pressure
  • asthma
  • heart, liver or kidney disease
  • diabetes
  • skin sensitive to light
  • history of depression.

If you have not told your doctor or pharmacist about any of the above, tell them before you take Prometrium.

Taking other medicines

Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop. Some medicines may affect the way other medicines work.

Some medicines may interfere with progesterone if taken at the same time. These include:

  • Carbamazepine, Phenobarbital and Phenytoin (medicines for epilepsy)
  • Rifampicin
  • Phenylbutazone
  • Spironolactone
  • Griseofulvin
  • Some antibiotics including ampicillins and tetracyclines
  • Bromocriptine
  • Cylosporin
  • Ketoconozole

These medicines may be affected by Prometrium or may affect how well they work. You may need different amounts of your medicine or you may need to use different medicines. Your doctor or pharmacist will advise you.

Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking Prometrium.

How to take Prometrium

How much to take

Your doctor or pharmacist will tell you how many capsules you need to take each day.

For women receiving hormone replacement therapy in conjunction with oestrogen with an intact uterus (womb), the usual dose is 200 mg/day at bedtime on days 15 to 26 of your cycle. You will usually have a few days withdrawal bleeding (like a period) after this time. Alternatively 100 mg can be taken at bedtime, from days 1 to 25 of each cycle, withdrawal bleeding being less with this treatment schedule.

For women with secondary amenorrhea (no menstrual periods), the treatment may be taken as a single daily dose of 400 mg at bedtime, for 10 days.

The standard daily dose is 200 to 300 mg of progesterone taken in one or two doses (i.e. 200 mg in the evening and another 100 mg in the morning, if needed).

In menstrual irregularities due to ovulation disorders, treatment is administered over 10 days per menstrual cycle, usually from days 17 to 26 inclusive.

Prometrium is to be taken by mouth and swallowed whole with a glass of water.

Do not take Prometrium with food as this may affect the way Prometrium works.

Follow all directions given to you by your doctor carefully. They may differ from the information contained in this leaflet.

How long to take it

The use of Prometrium may be continued for up to 10 days.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to, as usual.

Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.

Do not take a double dose to make up for the dose that you missed.

If you are not sure what to do, talk to your doctor or pharmacist. If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have taken too much Prometrium. Do this even if there are no signs of discomfort or poisoning.

Symptoms of an overdose with Prometrium include feeling dizzy or feeling tired.

While you are taking Prometrium

Things you must do

Tell any other doctors or pharmacists who are treating you that you are taking Prometrium.

If you are about to start taking any new medicines, tell your doctor or pharmacist that you are taking Prometrium.

Take special care and tell your doctor straight away if you experience any of these symptoms during treatment or even a few days after the last dosage:

  • pains in your calves or chest, a sudden shortness of breath or coughing up blood indicating possible clots in the legs, heart or lungs
  • severe headache or vomiting, dizziness, faintness or changes in vision or speech, weakness or numbness of an arm or leg indicating possible clots in the brain or eye
  • worsening symptoms of depression.

Things you must not do

Do not give Prometrium to anyone else, even if they have the same condition as you.

Do not take Prometrium to treat any other complaints unless your doctor has told you to.

Do not stop taking Prometrium or lower the dosage without checking with your doctor or pharmacist.

Things to be careful of

Be careful driving or operating machinery until you know how Prometrium affects you. Some people may experience drowsiness or dizziness. Make sure you know how you react to Prometrium before you drive a car, operate machinery or do anything else that could be dangerous if you are dizzy or light-headed. If this occurs, do not drive.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Prometrium.

Prometrium helps most people but it may have unwanted side effects in a few people.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

  • headache
  • abnormal breakthrough bleeding and/or vaginal bleeding or spotting or changes in cervical secretions
  • any significant change in your menstrual cycle, including loss of menstruation
  • unusual tiredness or weakness or weight gain
  • acne, breast pain or tenderness
  • mild mood changes, changes in libido and insomnia

The above list includes the more common side effects of your medicine. They are usually mild and short-lived.

Tell your doctor as soon as possible if you notice any of the following:

  • constipation
  • breast disorders (e.g. breast pain, breast swelling and breast tenderness)
  • headache, dizziness and drowsiness
  • mental depression
  • skin rash, itchiness (pruritus)

The above list includes serious side effects which may require medical attention. Serious side effects are rare.

If any of the following happen, stop taking Prometrium and tell your doctor immediately or go to Accident and Emergency at your nearest hospital:

  • Migraine
  • Loss of or change of speech, coordination or vision, pain or numbness in chest, arm or leg; unexplained shortness of breath, any symptoms of blood clots (thrombosis)
  • Yellowing of skin or eyes (jaundice)

These are very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are very rare.

Other side effects not listed above may also occur in some patients. Tell your doctor if you notice anything that is making you feel unwell.

Ask your doctor or pharmacist if you do not understand anything in this list.

Do not be alarmed by the list of possible side effects. You may not experience any of them.

After taking Prometrium


Keep this medicine in its original packaging until it is time to take them.

Keep this medicine in a cool dry place where the temperature stays below 30°C. DO NOT REFRIGERATE.

Do not store it or any other medicine in the bathroom or near a sink.

Do not leave it in the car or on window sills.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that are left over.

Product description

What it looks like

Prometrium 100 mg, soft capsule is a round, slightly yellow soft capsule, containing a whitish oily suspension. Prometrium 100 mg, soft capsule is supplied in blister strips packaged in an outer carton. Each carton contains 14, 15, 28, 30, 56, 84 or 90 capsules*.

Prometrium 200 mg, soft capsule is an ovoid slightly yellow soft capsule, containing a whitish oily suspension. Prometrium 200 mg, soft capsule is supplied in blister strips packaged in an outer carton. Each carton contains 7, 14, 15, 21, 28, 30, 42, 45, 56, 84 or 90* capsules.

* Not all pack sizes may be marketed.


Active ingredient:

  • progesterone 100 mg or 200 mg

Inactive ingredients:

  • sunflower oil
  • soya lecithin
  • gelatin
  • glycerol
  • titanium dioxide


Prometrium is supplied in Australia by:

Besins Healthcare Australia Pty Ltd
Level 23 Governor Macquarie Tower
1 Farrer Place
NSW 2000

This leaflet was prepared in April 2016.

Prometrium 100 mg, soft capsule AUST R 232818
Prometrium 200 mg, soft capsule AUST R 232823

Delivery info

Delivery Charges

  • FREE standard shipping on orders $80+ (save $6.95).

  • FREE express shipping* on orders $119+ (save $9.95)

  • Ordering a prescription item? You’ll automatically receive free standard shipping, too.** How good!

  • Same day delivery is offered for just $5 for orders $119 or more. For orders under $119, same day delivery costs $10.95.

* A shipping handling fee may apply at the checkout for orders weighing 10kg or more

** Any cold-chain items will carry a $9.95 Express Cold-Chain Shipping fee

*** Certain items and areas may be eligible for Same Day Delivery, and if selected will carry a $10.90 delivery fee


See shipping & returns policy for more details. 

Returns & exchanges

How Do Returns & Refunds Work?

All products you buy from the Healthylife website are covered by the Healthylife Returns Policy.

Please read our full Returns Policy to find out how to return a product that is faulty or if you have changed your mind.

How We Handle Them:

Change of Mind

  • If you've had a change of mind about an item you have ordered, we'll need to receive it back to us unopened and unused, in the original packaging.

Faulty Item

  • If the item you have received is faulty, please contact us with a detailed description of the product fault, alongside a photo if possible.

Allergic Reaction

  • In the rare instance you've had an allergic reaction to a product, please discontinue use of the product immediately. We may reach out for further information on the reaction.

Allergy returns must be less than 20% used upon arrival back to us.

Incorrect / Damaged Items

  • If you have received an item that isn't what you ordered, or it arrived damaged, please take a photo and contact us within 7 days of delivery. 

Please don't dispose of the item without informing us.

What Items Are Restricted For Returns*?

We will not accept Change of Mind Returns for the following items:

  • Rapid antigen tests
  • Baby formula
  • Prescription Medicine 
  • Compounded ‘Pharmacy Only’ Items 
  • Perfumes & Colognes 
  • Refrigerated Items 
  • Bulk / Special Orders 
  • Personalised items, digital downloads, prepaid cards or vouchers;
  • Clearance items;
  • Items that are advertised as not eligible for change of mind returns.